It's a suboptimal situation because chemotherapy improves relapse-free and colostomy-free survival, and possibly overall survival for all but the earliest stage patients. I would look into whether capecitabine alone might be an option as a radiosensitizer that might be more tolerable than mitomycin-...

I have cured a number of patients over the years with both early and locally advanced anal cancers with radiotherapy alone when ineligible or refuses chemotherapy. Radiotherapy alone works well for early node negative disease, which was underrepresented in randomized trials of concurrent chemo. I ev...

Same as above. If treating with RT alone, I consider going to a higher dose than I would have otherwise with chemoRT.

RT alone.