How would you approach a patient with a primary splenic DLBCL who has residual PET avid disease after 6 cycles of R-CHOP?

Topics: Hematologic Malignancies • Radiation Oncology

Would you consider radiation therapy? What dose/fractionation?

Answer from: Radiation Oncologist at Academic Institution

The treatment of DLBCL arising in the spleen would be very similar to the treatment of DLBCL at most other sites. After a full course of chemoimmunotherapy, if the patient has not achieved a complete response by PET-CT (Deauville 1-3), then the treating physicians need to make a judgment. The primar...

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Radiation Oncologist at OSF Saint Anthony Medical Center
Thank you Dr. @Christopher R. Kelsey. This patient...

Answer from: Radiation Oncologist at Community Practice

Prof. @Christopher R. Kelsey outlined treatment choices in a very elegant manner. Thank you for that! I would like to add that splenectomy could be considered instead of RT if the DLBCL was limited to the spleen at diagnosis.

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Medical Oncologist at NYU Langone Medical Center
Yes, in the above scenario, splenectomy could be b...

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